Altering cancer transcriptomes using epigenomic inhibitors
نویسندگان
چکیده
منابع مشابه
Epigenomic profiling using microarrays.
Genes occupy only a minor fraction of genomes such as ours; however, histone and nonhistone chromosomal proteins and methylated DNA bases are distributed over both genic and nongenic regions. These widespread "epigenomic" features can be mapped and characterized by alternative applications of the same microarray technologies that have been used for conventional transcriptional profiling. Here w...
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Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome. LncRNAs are a novel class of mRNA-like transcripts which, despite no known protein-coding potential, demonstrate a wide range of structural and functional roles in cellular biology. However, the magnitude of the contributio...
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ژورنال
عنوان ژورنال: Epigenetics & Chromatin
سال: 2015
ISSN: 1756-8935
DOI: 10.1186/1756-8935-8-9